Assay Detail
Functional
CHEMBL4340145
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Antimalarial activity against CQ-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as inhibition of parasite growth incubated for for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Covalent Inhibitors of <i>Plasmodium falciparum</i> Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.37 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436101 | — | — | 1 | 6.60 |
| CHEMBL3329248 | — | — | 1 | 6.58 |
| CHEMBL1971775 | — | — | 1 | 6.47 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.40 |
| CHEMBL4562798 | — | — | 1 | 6.32 |
| CHEMBL4467084 | — | — | 1 | 6.14 |
| CHEMBL3329246 | — | — | 1 | 6.06 |
| CHEMBL4581512 | — | — | 1 | - |
| CHEMBL4455992 | — | — | 1 | - |
| CHEMBL4589757 | — | — | 1 | - |
| CHEMBL4529769 | — | — | 1 | - |
| CHEMBL4446183 | — | — | 1 | - |
| CHEMBL4459115 | — | — | 1 | - |
| CHEMBL4465533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436101 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3329248 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1971775 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4562798 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4467084 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3329246 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4581512 | — | IC50 | - | — | - | |
| CHEMBL4455992 | — | IC50 | - | — | - | |
| CHEMBL4589757 | — | IC50 | - | — | - | |
| CHEMBL4529769 | — | IC50 | - | — | - | |
| CHEMBL4446183 | — | IC50 | - | — | - | |
| CHEMBL4459115 | — | IC50 | - | — | - | |
| CHEMBL4465533 | — | IC50 | - | — | - |