Assay Detail
ADMET
CHEMBL4340146
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Cytotoxicity in human HMEC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HMEC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Covalent Inhibitors of <i>Plasmodium falciparum</i> Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.61 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4562798 | — | — | 1 | 4.83 |
| CHEMBL1971775 | — | — | 1 | 4.71 |
| CHEMBL3329246 | — | — | 1 | 4.46 |
| CHEMBL4467084 | — | — | 1 | 4.44 |
| CHEMBL3329248 | — | — | 1 | - |
| CHEMBL4581512 | — | — | 1 | - |
| CHEMBL4455992 | — | — | 1 | - |
| CHEMBL4436101 | — | — | 1 | - |
| CHEMBL4589757 | — | — | 1 | - |
| CHEMBL4529769 | — | — | 1 | - |
| CHEMBL4446183 | — | — | 1 | - |
| CHEMBL4459115 | — | — | 1 | - |
| CHEMBL4465533 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4562798 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1971775 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL3329246 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL4467084 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL3329248 | — | IC50 | > | 65000.0 | nM | - |
| CHEMBL4581512 | — | IC50 | - | — | - | |
| CHEMBL4455992 | — | IC50 | - | — | - | |
| CHEMBL4436101 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4589757 | — | IC50 | - | — | - | |
| CHEMBL4529769 | — | IC50 | - | — | - | |
| CHEMBL4446183 | — | IC50 | - | — | - | |
| CHEMBL4459115 | — | IC50 | - | — | - | |
| CHEMBL4465533 | — | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 40000.0 | nM | - |