Assay Detail
Functional
CHEMBL4340230
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Antiproliferative activity against human KOPTK1 cells harboring activating Notch1 gene mutations assessed as reduction in cell viability incubated for 36 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KOPTK1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.75 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576806 | — | — | 1 | 6.14 |
| CHEMBL4556946 | — | — | 1 | 5.86 |
| CHEMBL2333805 | — | — | 1 | 5.72 |
| CHEMBL4470333 | — | — | 1 | 5.61 |
| CHEMBL4471467 | — | — | 1 | 5.42 |
| CHEMBL4445762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576806 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4556946 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL2333805 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4470333 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4471467 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4445762 | — | IC50 | - | — | - |