Assay Detail
Binding
CHEMBL4340308
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Inhibition of BACE1 (unknown origin) using Rh-EVNNLDAEFK-Quencher substrate incubated for 3 hrs by FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of Boletinus asiaticus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378225 | — | — | 1 | 7.82 |
| CHEMBL4443976 | — | — | 1 | 5.70 |
| CHEMBL4576721 | — | — | 1 | 4.94 |
| CHEMBL4533100 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378225 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4443976 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4576721 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4533100 | — | IC50 | = | 14700.0 | nM | 4.83 |