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Assay Detail

CHEMBL4340461

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Cryptococcus neoformans ATCC 90113 assessed as inhibition of microbial growth by CLSI based method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cryptococcus neoformans
Confidence 1 — Organism
Curated By Autocuration

Target

Cryptococcus neoformans (CHEMBL365)
Type ORGANISM
Organism Cryptococcus neoformans

Publication

Anthraquinone-Based Specialized Metabolites from Rhizomes of <i>Bulbine natalensis</i>.
Bae JY, Ali Z, Wang YH, Chittiboyina AG, Zaki AA, Viljoen AM, Khan IA.
J Nat Prod (2019) 82 : 1893 -1901
PubMed 31287681 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 9.00 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 9.70
CHEMBL106 FLUCONAZOLE 4.0 1 8.30
CHEMBL4460626 1 -
CHEMBL8 CIPROFLOXACIN 4.0 1 -
CHEMBL262777 VANCOMYCIN 4.0 1 -
CHEMBL575 METHICILLIN 4.0 1 -
CHEMBL1730 CEFOTAXIME 4.0 1 -
CHEMBL127 MEROPENEM 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 0.2 nM 9.70
CHEMBL106 FLUCONAZOLE IC50 = 5.0 nM 8.30
CHEMBL4460626 IC50 > 30.0 nM -
CHEMBL8 CIPROFLOXACIN IC50 > 30.0 nM -
CHEMBL262777 VANCOMYCIN IC50 > 70.0 nM -
CHEMBL575 METHICILLIN IC50 > 300.0 nM -
CHEMBL1730 CEFOTAXIME IC50 > 200.0 nM -
CHEMBL127 MEROPENEM IC50 > 300.0 nM -