Assay Detail
Functional
CHEMBL4340841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1299 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.29 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214827 | ONALESPIB | 2.0 | 1 | 6.43 |
| CHEMBL4513831 | — | — | 1 | 5.47 |
| CHEMBL393417 | DEGUELIN | — | 1 | 5.25 |
| CHEMBL4467932 | — | — | 1 | 5.24 |
| CHEMBL4553759 | — | — | 1 | 5.14 |
| CHEMBL2177146 | — | — | 1 | 4.93 |
| CHEMBL4450592 | — | — | 1 | 4.92 |
| CHEMBL4580915 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214827 | ONALESPIB | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4513831 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL393417 | DEGUELIN | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL4467932 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4553759 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2177146 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL4450592 | — | IC50 | = | 12030.0 | nM | 4.92 |
| CHEMBL4580915 | — | IC50 | = | 12610.0 | nM | 4.90 |