Assay Detail
Binding
CHEMBL4341981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-FAM-tagged Bid-BH3 peptide binding to Mcl1 (unknown origin) by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.32 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1331211 | — | — | 1 | 6.75 |
| CHEMBL4439398 | — | — | 1 | 6.36 |
| CHEMBL4544703 | — | — | 1 | 6.32 |
| CHEMBL4482922 | — | — | 1 | 6.31 |
| CHEMBL4515351 | — | — | 1 | 6.28 |
| CHEMBL4439691 | — | — | 1 | 6.28 |
| CHEMBL3401826 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1331211 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL4439398 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL4544703 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL4482922 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL4515351 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL4439691 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL3401826 | — | Ki | = | 1100.0 | nM | 5.96 |