Assay Detail
Binding
CHEMBL4342371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced whole cell currents by patch-clamp technique
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
11-Aminostrychnine and <i>N</i>-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.92 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | -1.0 | 1 | 7.29 |
| CHEMBL4518537 | — | — | 1 | 6.76 |
| CHEMBL4447664 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4518537 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4447664 | — | IC50 | = | 194.0 | nM | 6.71 |