Assay Detail
Binding
CHEMBL4342533
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Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluorescence based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cathepsin B: Active site mapping with peptidic substrates and inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.79 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336228 | — | — | 1 | 8.74 |
| CHEMBL4582255 | — | — | 1 | 7.92 |
| CHEMBL342145 | — | — | 1 | 6.30 |
| CHEMBL344174 | — | — | 1 | 4.21 |
| CHEMBL138499 | — | — | 1 | - |
| CHEMBL134083 | — | — | 1 | - |
| CHEMBL337090 | — | — | 1 | - |
| CHEMBL141793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336228 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4582255 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL342145 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL344174 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL138499 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL134083 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL337090 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL141793 | — | IC50 | < | 10.0 | nM | - |