Assay Detail
Binding
CHEMBL4342718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain MAO-A using 14C-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.39 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356385 | — | — | 1 | 4.70 |
| CHEMBL4579904 | — | — | 1 | 4.07 |
| CHEMBL4473282 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356385 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4579904 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4473282 | — | IC50 | = | 375000.0 | nM | - |