Assay Detail
Binding
CHEMBL4342889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SRC (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.27 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 8.57 |
| CHEMBL3109738 | JNJ-26483327 | 1.0 | 1 | 7.96 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217092 | SARACATINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3109738 | JNJ-26483327 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 110000.0 | nM | - |