Assay Detail
ADMET
CHEMBL4343418
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Inhibition of cathepsin E (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.12 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564735 | — | — | 1 | 7.12 |
| CHEMBL4560579 | — | — | 1 | - |
| CHEMBL4577527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564735 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4560579 | — | IC50 | = | 1377000.0 | nM | - |
| CHEMBL4577527 | — | IC50 | = | 453000.0 | nM | - |