Assay Detail
Binding
CHEMBL4343698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length Trypanosoma cruzi Tulahuen C4 C-terminal His-tagged CYP51 expressed in Escherichia coli HMS174 (DE3) assessed as induction of shift in Soret band by spectrophotometry
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sterol 14-alpha demethylase (CHEMBL1075110) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi (strain CL Brener) |
Publication
A new chemotype with promise against Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.82 | 7.75 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 1 | 7.75 |
| CHEMBL3105168 | — | — | 1 | 5.88 |
| CHEMBL4448813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL3105168 | — | Kd | = | 1320.0 | nM | 5.88 |
| CHEMBL4448813 | — | Activity | - | — | - |