Assay Detail
Binding
CHEMBL4344002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-cGAMP from full length STING HAQ mutant in human THP1 cells by filtration binding assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.34 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465286 | — | — | 1 | 8.92 |
| CHEMBL4456045 | — | — | 1 | 8.77 |
| CHEMBL4568160 | — | — | 1 | 7.93 |
| CHEMBL4553220 | — | — | 1 | 7.67 |
| CHEMBL4476354 | — | — | 1 | 7.61 |
| CHEMBL4468545 | — | — | 1 | 6.28 |
| CHEMBL4562620 | — | — | 1 | 6.22 |
| CHEMBL4575454 | — | — | 1 | 6.05 |
| CHEMBL4436937 | — | — | 1 | 5.86 |
| CHEMBL4434776 | — | — | 1 | 5.76 |
| CHEMBL4467434 | — | — | 1 | 5.58 |
| CHEMBL4570444 | — | — | 1 | 5.56 |
| CHEMBL4528146 | — | — | 1 | 5.39 |
| CHEMBL4475752 | — | — | 1 | 5.26 |
| CHEMBL4574326 | — | — | 1 | 5.22 |
| CHEMBL4440309 | — | — | 1 | 5.02 |
| CHEMBL4436665 | — | — | 1 | 4.75 |
| CHEMBL4556279 | — | — | 1 | - |
| CHEMBL4525655 | — | — | 1 | - |
| CHEMBL4521873 | — | — | 1 | - |
| CHEMBL4474321 | — | — | 1 | - |
| CHEMBL4459212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465286 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4456045 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4568160 | — | EC50 | = | 11.7 | nM | 7.93 |
| CHEMBL4553220 | — | EC50 | = | 21.5 | nM | 7.67 |
| CHEMBL4476354 | — | EC50 | = | 24.6 | nM | 7.61 |
| CHEMBL4468545 | — | EC50 | = | 531.0 | nM | 6.28 |
| CHEMBL4562620 | — | EC50 | = | 599.0 | nM | 6.22 |
| CHEMBL4575454 | — | EC50 | = | 894.0 | nM | 6.05 |
| CHEMBL4436937 | — | EC50 | = | 1375.0 | nM | 5.86 |
| CHEMBL4434776 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4467434 | — | EC50 | = | 2636.0 | nM | 5.58 |
| CHEMBL4570444 | — | EC50 | = | 2735.0 | nM | 5.56 |
| CHEMBL4528146 | — | EC50 | = | 4073.0 | nM | 5.39 |
| CHEMBL4475752 | — | EC50 | = | 5547.0 | nM | 5.26 |
| CHEMBL4574326 | — | EC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL4440309 | — | EC50 | = | 9587.0 | nM | 5.02 |
| CHEMBL4436665 | — | EC50 | = | 17840.0 | nM | 4.75 |
| CHEMBL4556279 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL4525655 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL4521873 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL4474321 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL4459212 | — | EC50 | < | 1.0 | nM | - |