Assay Detail
Binding
CHEMBL4344045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucoside as substrate preincubated for 0.5 hrs followed substrate addition and measured after 1 hr by colorimetric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phloroglucinol Benzophenones and Xanthones from the Leaves of <i>Garcinia cowa</i> and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.52 | 4.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561643 | MANGOSTANIN | — | 1 | 4.94 |
| CHEMBL4564699 | — | — | 1 | 4.81 |
| CHEMBL261706 | — | — | 1 | 4.65 |
| CHEMBL4580552 | — | — | 1 | 4.59 |
| CHEMBL4451474 | — | — | 1 | 4.54 |
| CHEMBL458845 | COWANIN | — | 1 | 4.43 |
| CHEMBL4561697 | — | — | 1 | 4.12 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561643 | MANGOSTANIN | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4564699 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL261706 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4580552 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4451474 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL458845 | COWANIN | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL4561697 | — | IC50 | = | 76200.0 | nM | 4.12 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 80000.0 | nM | 4.10 |