Assay Detail
Binding
CHEMBL4344285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.04 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456029 | — | — | 1 | 7.77 |
| CHEMBL4297354 | AZD-7687 | 1.0 | 1 | 7.10 |
| CHEMBL4530491 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456029 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4297354 | AZD-7687 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4530491 | — | IC50 | = | 579.0 | nM | 6.24 |