Assay Detail
Binding
CHEMBL4344313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged human Mcl1 expressed in Escherichia coli Rosetta2 DE3 by fluorescent labeled Flu-Bid peptide based fluorescence polarization assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.90 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522193 | — | — | 1 | 7.14 |
| CHEMBL4533559 | — | — | 1 | 7.13 |
| CHEMBL4462138 | — | — | 1 | 7.06 |
| CHEMBL4558313 | — | — | 1 | 7.05 |
| CHEMBL4576854 | — | — | 1 | 7.03 |
| CHEMBL4463305 | — | — | 1 | 6.70 |
| CHEMBL4457901 | — | — | 1 | 6.66 |
| CHEMBL4454113 | — | — | 1 | 6.54 |
| CHEMBL4452560 | — | — | 1 | 6.48 |
| CHEMBL4475729 | — | — | 1 | 6.24 |
| CHEMBL4440719 | — | — | 1 | 6.11 |
| CHEMBL4435041 | — | — | 1 | 6.09 |
| CHEMBL4473975 | — | — | 1 | 6.08 |
| CHEMBL4525910 | — | — | 1 | 6.02 |
| CHEMBL4448621 | — | — | 1 | 5.82 |
| CHEMBL4577267 | — | — | 1 | 5.77 |
| CHEMBL4463594 | — | — | 1 | 5.70 |
| CHEMBL4461974 | — | — | 1 | 5.58 |
| CHEMBL4435893 | — | — | 1 | 5.57 |
| CHEMBL4442233 | — | — | 1 | 5.47 |
| CHEMBL4459843 | — | — | 1 | 5.33 |
| CHEMBL4528399 | — | — | 1 | 5.21 |
| CHEMBL4534654 | — | — | 1 | 4.88 |
| CHEMBL4553113 | — | — | 1 | 4.72 |
| CHEMBL4456253 | — | — | 1 | 4.48 |
| CHEMBL285503 | — | — | 1 | 4.32 |
| CHEMBL4461424 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522193 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4533559 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL4462138 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL4558313 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL4576854 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL4463305 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4457901 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4454113 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4452560 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL4475729 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL4440719 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL4435041 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL4473975 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL4525910 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL4448621 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4577267 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4463594 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4461974 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL4435893 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL4442233 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4459843 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL4528399 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL4534654 | — | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL4553113 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL4456253 | — | Ki | = | 32800.0 | nM | 4.48 |
| CHEMBL285503 | — | Ki | = | 47800.0 | nM | 4.32 |
| CHEMBL4461424 | — | Ki | = | 70400.0 | nM | 4.15 |