Assay Detail
Binding
CHEMBL4344316
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Binding affinity to immobilized biotin-labeled and N-terminal His6-tagged human Bfl-1 (1 to 151 residues), expressed in Escherichia coli Rosetta2 DE3 by biolayer interferometry
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| Kd | 2 | 5.97 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522193 | — | — | 2 | 6.04 |
| CHEMBL4576854 | — | — | 2 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522193 | — | Kd | = | 920.0 | nM | 6.04 |
| CHEMBL4576854 | — | Kd | = | 1270.0 | nM | 5.90 |
| CHEMBL4522193 | — | Activity | - | — | - | |
| CHEMBL4576854 | — | Activity | - | — | - |