Assay Detail
Binding
CHEMBL4344595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine GUS pre-incubated for 5 to 30 mins before 4-methylumbelliferone beta-D-glucuronide substrate addition at pH 4.5
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.73 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4589187 | — | — | 1 | 7.32 |
| CHEMBL1232598 | — | — | 1 | 6.88 |
| CHEMBL4589322 | — | — | 1 | 5.31 |
| CHEMBL442895 | — | — | 1 | 4.67 |
| CHEMBL4451253 | — | — | 1 | 4.49 |
| CHEMBL4441158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4589187 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1232598 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL4589322 | — | Ki | = | 4870.0 | nM | 5.31 |
| CHEMBL442895 | — | Ki | = | 21470.0 | nM | 4.67 |
| CHEMBL4451253 | — | Ki | = | 32230.0 | nM | 4.49 |
| CHEMBL4441158 | — | Ki | = | 187300.0 | nM | - |