Assay Detail
ADMET
CHEMBL4344884
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Displacement of fluorescein labeled ATP probe from His/GST-tagged RIPK2 (unknown origin) incubated for 60 mins by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL5014) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.57 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476485 | — | — | 1 | 6.17 |
| CHEMBL4455682 | — | — | 1 | 5.75 |
| CHEMBL4552106 | — | — | 1 | 5.52 |
| CHEMBL4476076 | — | — | 1 | 5.51 |
| CHEMBL4542026 | — | — | 1 | 4.89 |
| CHEMBL509101 | — | — | 1 | - |
| CHEMBL4572309 | — | — | 1 | - |
| CHEMBL4468222 | — | — | 1 | - |
| CHEMBL4434881 | — | — | 1 | - |
| CHEMBL4438939 | — | — | 1 | - |
| CHEMBL4551490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476485 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4455682 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4552106 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4476076 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4542026 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL509101 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4572309 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4468222 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4434881 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4438939 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL4551490 | — | IC50 | > | 10000.0 | nM | - |