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Assay Detail

CHEMBL4345202

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Binding
Binding affinity to wild type human partial length PIP5K1C (M1 to T668 residues) expressed in mammalian expression system by Kinomescan method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD.
ACS Med Chem Lett (2020) 11 : 340 -345
PubMed 32184967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.58 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4452939 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4452939 Kd = 260.0 nM 6.58