Assay Detail
Binding
CHEMBL4345253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using dGTP as substrate measured after 30 mins by malachite green dye based inorganic phosphatase coupled absorbance assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxidized purine nucleoside triphosphate hydrolase (CHEMBL3708265) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.70 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781316 | — | — | 1 | 9.10 |
| CHEMBL3782004 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781316 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3782004 | — | IC50 | = | 5.0 | nM | 8.30 |