Assay Detail
Functional
CHEMBL4345256
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.11 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781316 | — | — | 1 | 6.16 |
| CHEMBL3782004 | — | — | 1 | 5.25 |
| CHEMBL1825141 | — | — | 1 | 5.17 |
| CHEMBL4436749 | — | — | 1 | 5.09 |
| CHEMBL4565569 | — | — | 1 | 4.84 |
| CHEMBL4570428 | — | — | 1 | 4.69 |
| CHEMBL4435983 | — | — | 1 | 4.60 |
| CHEMBL3793901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781316 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3782004 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1825141 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4436749 | — | EC50 | = | 8048.0 | nM | 5.09 |
| CHEMBL4565569 | — | EC50 | = | 14416.0 | nM | 4.84 |
| CHEMBL4570428 | — | EC50 | = | 20323.0 | nM | 4.69 |
| CHEMBL4435983 | — | EC50 | = | 24916.0 | nM | 4.60 |
| CHEMBL3793901 | — | EC50 | > | 20000.0 | nM | - |