Assay Detail
Functional
CHEMBL4345342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.78 | 9.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467483 | — | — | 2 | 9.91 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 2 | 7.00 |
| CHEMBL4564103 | — | — | 2 | 6.44 |
| CHEMBL4579687 | — | — | 2 | 5.49 |
| CHEMBL4513262 | — | — | 2 | 5.05 |
| CHEMBL4442011 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467483 | — | IC50 | = | 0.123 | nM | 9.91 |
| CHEMBL4467483 | — | IC50 | = | 0.124 | nM | 9.91 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 104.2 | nM | 6.98 |
| CHEMBL4564103 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL4564103 | — | IC50 | = | 365.2 | nM | 6.44 |
| CHEMBL4579687 | — | IC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL4579687 | — | IC50 | = | 3222.0 | nM | 5.49 |
| CHEMBL4513262 | — | IC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL4513262 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4442011 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442011 | — | IC50 | > | 10000.0 | nM | - |