Assay Detail
Binding
CHEMBL4345635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC or Boc-Lys (triflouroacetyl)-AMC addition and measured after 30 mins by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.26 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576202 | — | — | 1 | 8.06 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.14 |
| CHEMBL4456886 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576202 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL4456886 | — | IC50 | = | 255.0 | nM | 6.59 |