Assay Detail
ADMET
CHEMBL4345652
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Antiproliferative activity against human GES-1 cells incubated for 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | GES1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.90 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.90 |
| CHEMBL4456886 | — | — | 1 | 7.57 |
| CHEMBL4576202 | — | — | 1 | 6.78 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL4456886 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL4576202 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4690.0 | nM | 5.33 |