Assay Detail
Functional
CHEMBL4345664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against bortezomib resistant human KM3/BTZ cells incubated for 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM3/BTZ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.68 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456886 | — | — | 1 | 8.05 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 6.82 |
| CHEMBL4576202 | — | — | 1 | 6.80 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.65 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456886 | — | IC50 | = | 8.98 | nM | 8.05 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4576202 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2040.0 | nM | 5.69 |