Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4345696

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

B-cell lymphoma 6 protein (CHEMBL4105786) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Bellenie BR, Cheung KJ, Varela A, Pierrat OA, Collie GW, Box GM, Bright MD, Gowan S, Hayes A, Rodrigues MJ, Shetty KN, Carter M, Davis OA, Henley AT, Innocenti P, Johnson LD, Liu M, de Klerk S, Le Bihan YV, Lloyd MG, McAndrew PC, Shehu E, Talbot R, Woodward HL, Burke R, Kirkin V, van Montfort RLM, Raynaud FI, Rossanese OW, Hoelder S.
J Med Chem (2020) 63 : 4047 -4068
PubMed 32275432 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 6.07 7.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4559074 — — 1 7.07
CHEMBL4574515 — — 1 7.01
CHEMBL4465387 — — 1 6.89
CHEMBL4476234 — — 1 6.82
CHEMBL4458261 — — 1 6.72
CHEMBL4573672 — — 1 6.70
CHEMBL4524719 — — 1 6.64
CHEMBL4451702 — — 1 6.58
CHEMBL4463841 — — 1 6.57
CHEMBL4587209 — — 1 6.51
CHEMBL4439574 — — 1 6.48
CHEMBL4466680 — — 1 6.41
CHEMBL4482923 — — 1 6.40
CHEMBL4583696 — — 1 6.40
CHEMBL4450499 — — 1 6.37
CHEMBL4475529 — — 1 6.32
CHEMBL4445645 — — 1 6.28
CHEMBL4459012 — — 1 6.19
CHEMBL4483413 — — 1 6.17
CHEMBL4525209 — — 1 6.15
CHEMBL4548894 — — 1 6.15
CHEMBL4547183 — — 1 6.12
CHEMBL4467613 — — 1 6.10
CHEMBL4572689 — — 1 6.07
CHEMBL4475438 — — 1 6.03
CHEMBL4457011 — — 1 6.02
CHEMBL4469177 — — 1 6.00
CHEMBL4451202 — — 1 6.00
CHEMBL4531272 — — 1 5.92
CHEMBL4576646 — — 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4559074 — IC50 = 86.0 nM 7.07
CHEMBL4574515 — IC50 = 97.0 nM 7.01
CHEMBL4465387 — IC50 = 130.0 nM 6.89
CHEMBL4476234 — IC50 = 150.0 nM 6.82
CHEMBL4458261 — IC50 = 190.0 nM 6.72
CHEMBL4573672 — IC50 = 200.0 nM 6.70
CHEMBL4524719 — IC50 = 230.0 nM 6.64
CHEMBL4451702 — IC50 = 260.0 nM 6.58
CHEMBL4463841 — IC50 = 270.0 nM 6.57
CHEMBL4587209 — IC50 = 310.0 nM 6.51
CHEMBL4439574 — IC50 = 330.0 nM 6.48
CHEMBL4466680 — IC50 = 390.0 nM 6.41
CHEMBL4482923 — IC50 = 400.0 nM 6.40
CHEMBL4583696 — IC50 = 400.0 nM 6.40
CHEMBL4450499 — IC50 = 430.0 nM 6.37
CHEMBL4475529 — IC50 = 480.0 nM 6.32
CHEMBL4445645 — IC50 = 520.0 nM 6.28
CHEMBL4459012 — IC50 = 640.0 nM 6.19
CHEMBL4483413 — IC50 = 680.0 nM 6.17
CHEMBL4525209 — IC50 = 710.0 nM 6.15
CHEMBL4548894 — IC50 = 710.0 nM 6.15
CHEMBL4547183 — IC50 = 760.0 nM 6.12
CHEMBL4467613 — IC50 = 790.0 nM 6.10
CHEMBL4572689 — IC50 = 860.0 nM 6.07
CHEMBL4475438 — IC50 = 930.0 nM 6.03
CHEMBL4457011 — IC50 = 960.0 nM 6.02
CHEMBL4469177 — IC50 = 1000.0 nM 6.00
CHEMBL4451202 — IC50 = 990.0 nM 6.00
CHEMBL4531272 — IC50 = 1200.0 nM 5.92
CHEMBL4576646 — IC50 = 1400.0 nM 5.85
CHEMBL4457356 — IC50 = 1400.0 nM 5.85
CHEMBL4550751 — IC50 = 1700.0 nM 5.77
CHEMBL4556514 — IC50 = 1900.0 nM 5.72
CHEMBL4456923 — IC50 = 2100.0 nM 5.68
CHEMBL4554124 — IC50 = 2500.0 nM 5.60
CHEMBL4555389 — IC50 = 3400.0 nM 5.47
CHEMBL4542555 — IC50 = 3400.0 nM 5.47
CHEMBL4560573 — IC50 = 3500.0 nM 5.46
CHEMBL4521627 — IC50 = 3900.0 nM 5.41
CHEMBL4437454 — IC50 = 4500.0 nM 5.35
CHEMBL4550911 — IC50 = 4600.0 nM 5.34
CHEMBL4525917 — IC50 = 5400.0 nM 5.27
CHEMBL4473868 — IC50 = 6600.0 nM 5.18
CHEMBL4556362 — IC50 = 37000.0 nM 4.43