Assay Detail
Binding
CHEMBL4345698
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Inhibition of recombinant human Nanoluc-tagged BCL6/Halo-tagged SMRT transfected in human HEK293T cells assessed as reduction in BCL6/SMRT interaction incubated for 6 hrs by NANOBRET assay
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.46 | 6.22 |
| DC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574515 | — | — | 1 | 6.22 |
| CHEMBL4458261 | — | — | 1 | 5.81 |
| CHEMBL4451702 | — | — | 1 | 5.75 |
| CHEMBL4476234 | — | — | 1 | 5.75 |
| CHEMBL4463841 | — | — | 1 | 5.64 |
| CHEMBL4583696 | — | — | 1 | 5.60 |
| CHEMBL4450499 | — | — | 1 | 5.57 |
| CHEMBL4467613 | — | — | 1 | 5.34 |
| CHEMBL4475529 | — | — | 1 | 5.34 |
| CHEMBL4475438 | — | — | 1 | 5.30 |
| CHEMBL4548894 | — | — | 1 | 5.23 |
| CHEMBL4459012 | — | — | 1 | 4.89 |
| CHEMBL4547183 | — | — | 1 | 4.52 |
| CHEMBL4531272 | — | — | 1 | - |
| CHEMBL4457356 | — | — | 1 | - |
| CHEMBL4560573 | — | — | 1 | - |
| CHEMBL4469177 | — | — | 1 | - |
| CHEMBL4542555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574515 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4458261 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4451702 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4476234 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4463841 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4583696 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4450499 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4467613 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4475529 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4475438 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4548894 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4459012 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4547183 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4531272 | — | IC50 | - | — | - | |
| CHEMBL4457356 | — | IC50 | - | — | - | |
| CHEMBL4560573 | — | IC50 | - | — | - | |
| CHEMBL4469177 | — | IC50 | - | — | - | |
| CHEMBL4542555 | — | DC50 | > | 30.0 | uM | - |