Assay Detail
Functional
CHEMBL4345846
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Antileishmanial activity against Leishmania donovani BOB (MHOM/SD/62/1S-CL2D) promastigotes overexpressing NTR2 assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.47 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559873 | — | — | 1 | 5.68 |
| CHEMBL4565434 | — | — | 1 | 5.54 |
| CHEMBL4170207 | — | — | 1 | 5.34 |
| CHEMBL4556532 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559873 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4565434 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4170207 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4556532 | — | EC50 | = | 4900.0 | nM | 5.31 |