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Assay Detail

CHEMBL4345898

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IDO1 in human A172 cells after 24 hrs in presence of IFNgamma by NFK green reagent based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Parr BT, Pastor R, Sellers BD, Pei Z, Jaipuri FA, Castanedo GM, Gazzard L, Kumar S, Li X, Liu W, Mendonca R, Pavana RK, Potturi H, Shao C, Velvadapu V, Waldo JP, Wu G, Yuen PW, Zhang Z, Zhang Y, Harris SF, Oh AJ, DiPasquale A, Dement K, La H, Goon L, Gustafson A, VanderPorten EC, Mautino MR, Liu Y.
ACS Med Chem Lett (2020) 11 : 541 -549
PubMed 32292562 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 5.81 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3752060 1 6.89
CHEMBL4577396 1 6.62
CHEMBL4468203 1 6.38
CHEMBL4593111 1 6.17
CHEMBL4541824 1 6.16
CHEMBL4445816 1 6.14
CHEMBL4437257 1 6.10
CHEMBL4520696 1 6.06
CHEMBL4542307 1 6.01
CHEMBL4539108 1 5.89
CHEMBL4555603 1 5.85
CHEMBL4447185 1 5.85
CHEMBL4548068 1 5.80
CHEMBL4531114 1 5.66
CHEMBL4544695 1 5.58
CHEMBL4540245 1 5.54
CHEMBL4439294 1 5.35
CHEMBL4590789 1 5.34
CHEMBL4589215 1 5.00
CHEMBL4440730 1 4.89
CHEMBL4558670 1 4.70
CHEMBL4473543 1 -
CHEMBL4529817 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3752060 EC50 = 130.0 nM 6.89
CHEMBL4577396 EC50 = 240.0 nM 6.62
CHEMBL4468203 EC50 = 420.0 nM 6.38
CHEMBL4593111 EC50 = 670.0 nM 6.17
CHEMBL4541824 EC50 = 690.0 nM 6.16
CHEMBL4445816 EC50 = 720.0 nM 6.14
CHEMBL4437257 EC50 = 800.0 nM 6.10
CHEMBL4520696 EC50 = 880.0 nM 6.06
CHEMBL4542307 EC50 = 970.0 nM 6.01
CHEMBL4539108 EC50 = 1300.0 nM 5.89
CHEMBL4555603 EC50 = 1400.0 nM 5.85
CHEMBL4447185 EC50 = 1400.0 nM 5.85
CHEMBL4548068 EC50 = 1600.0 nM 5.80
CHEMBL4531114 EC50 = 2200.0 nM 5.66
CHEMBL4544695 EC50 = 2600.0 nM 5.58
CHEMBL4540245 EC50 = 2900.0 nM 5.54
CHEMBL4439294 EC50 = 4500.0 nM 5.35
CHEMBL4590789 EC50 = 4600.0 nM 5.34
CHEMBL4589215 EC50 = 10000.0 nM 5.00
CHEMBL4440730 EC50 = 13000.0 nM 4.89
CHEMBL4558670 EC50 = 20000.0 nM 4.70
CHEMBL4473543 EC50 > 25000.0 nM -
CHEMBL4529817 EC50 > 25000.0 nM -