Assay Detail
Binding
CHEMBL4345962
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Inhibition of Thermotoga maritima membrane bound pyrophosphatase at 100 uM using sodium pyrophosphate as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometry
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Thermotoga maritima |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.39 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450956 | — | — | 1 | 5.21 |
| CHEMBL4535012 | — | — | 1 | 5.17 |
| CHEMBL4469045 | — | — | 1 | 5.16 |
| CHEMBL4450656 | — | — | 1 | 5.00 |
| CHEMBL4447298 | — | — | 1 | 4.77 |
| CHEMBL4455679 | — | — | 1 | 4.58 |
| CHEMBL4572726 | — | — | 1 | 4.54 |
| CHEMBL4519360 | — | — | 1 | 4.44 |
| CHEMBL4538913 | — | — | 1 | 4.41 |
| CHEMBL4541663 | — | — | 1 | 4.37 |
| CHEMBL4443065 | — | — | 1 | 4.33 |
| CHEMBL4460656 | — | — | 1 | 4.33 |
| CHEMBL4527020 | — | — | 1 | 4.32 |
| CHEMBL4561512 | — | — | 1 | 4.15 |
| CHEMBL4449032 | — | — | 1 | 4.14 |
| CHEMBL4445272 | — | — | 1 | 4.10 |
| CHEMBL4445278 | — | — | 1 | 4.04 |
| CHEMBL4556117 | — | — | 1 | 4.00 |
| CHEMBL1488867 | — | — | 1 | 3.96 |
| CHEMBL4558002 | — | — | 1 | 3.92 |
| CHEMBL397785 | — | — | 1 | 3.89 |
| CHEMBL1621095 | — | — | 1 | 3.68 |
| CHEMBL4559968 | — | — | 1 | - |
| CHEMBL4473478 | — | — | 1 | - |
| CHEMBL1543647 | — | — | 1 | - |
| CHEMBL4466417 | — | — | 1 | - |
| CHEMBL455953 | — | — | 1 | - |
| CHEMBL4472150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450956 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4535012 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4469045 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4450656 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4447298 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4455679 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4572726 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4519360 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4538913 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4541663 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4443065 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4460656 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4527020 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4561512 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4449032 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4445272 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4445278 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL4556117 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1488867 | — | IC50 | = | 110000.0 | nM | 3.96 |
| CHEMBL4558002 | — | IC50 | = | 120000.0 | nM | 3.92 |
| CHEMBL397785 | — | IC50 | = | 130000.0 | nM | 3.89 |
| CHEMBL1621095 | — | IC50 | = | 210000.0 | nM | 3.68 |
| CHEMBL4559968 | — | IC50 | - | — | - | |
| CHEMBL4473478 | — | IC50 | - | — | - | |
| CHEMBL1543647 | — | IC50 | - | — | - | |
| CHEMBL4466417 | — | IC50 | = | 460000.0 | nM | - |
| CHEMBL455953 | — | IC50 | - | — | - | |
| CHEMBL4472150 | — | IC50 | - | — | - |