Assay Detail
Functional
CHEMBL4346336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SKM1 cells assessed as reduction in cell viability after 5 days by CellTiter-Glo assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKM-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.70 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4529861 | — | — | 1 | 8.77 |
| CHEMBL4454614 | — | — | 1 | 8.60 |
| CHEMBL4461291 | — | — | 1 | 8.59 |
| CHEMBL4470856 | — | — | 1 | 8.48 |
| CHEMBL4548794 | — | — | 1 | 8.48 |
| CHEMBL4435166 | — | — | 1 | 8.46 |
| CHEMBL4465299 | — | — | 1 | 8.38 |
| CHEMBL4462804 | — | — | 1 | 8.28 |
| CHEMBL4555714 | — | — | 1 | 8.21 |
| CHEMBL4469571 | — | — | 1 | 8.21 |
| CHEMBL3915707 | — | — | 1 | 8.18 |
| CHEMBL4297454 | ABBV-744 | 1.0 | 1 | 8.17 |
| CHEMBL4455576 | — | — | 1 | 8.17 |
| CHEMBL4471851 | — | — | 1 | 8.15 |
| CHEMBL4539875 | — | — | 1 | 8.02 |
| CHEMBL4434761 | — | — | 1 | 8.01 |
| CHEMBL3964225 | — | — | 1 | 8.00 |
| CHEMBL4452278 | — | — | 1 | 8.00 |
| CHEMBL4483338 | — | — | 1 | 7.96 |
| CHEMBL4467038 | — | — | 1 | 7.96 |
| CHEMBL4552305 | — | — | 1 | 7.89 |
| CHEMBL4461289 | — | — | 1 | 7.85 |
| CHEMBL4589568 | — | — | 1 | 7.85 |
| CHEMBL4442074 | — | — | 1 | 7.85 |
| CHEMBL4449740 | — | — | 1 | 7.72 |
| CHEMBL4564879 | — | — | 1 | 7.70 |
| CHEMBL4555653 | — | — | 1 | 7.68 |
| CHEMBL4443563 | — | — | 1 | 7.64 |
| CHEMBL4586647 | — | — | 1 | 7.62 |
| CHEMBL4587188 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4529861 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4454614 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4461291 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4470856 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4548794 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4435166 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4465299 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4462804 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4555714 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4469571 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3915707 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4297454 | ABBV-744 | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4455576 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4471851 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4539875 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4434761 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3964225 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4452278 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4483338 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4467038 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4552305 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4461289 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4589568 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4442074 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4449740 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4564879 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4555653 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4443563 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4586647 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4587188 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4455214 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4464739 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4547415 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4454597 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4560574 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4440089 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4466931 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4533567 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4590365 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4551285 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4554545 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4521111 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4568610 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4584480 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4548127 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4453740 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4452861 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4457805 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4579396 | — | IC50 | = | 3100.0 | nM | 5.51 |