Assay Detail
Binding
CHEMBL4346794
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Inhibition of CDK4 (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.08 | 7.68 |
| Ki | 3 | 7.28 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579344 | — | — | 1 | 7.68 |
| CHEMBL298445 | — | — | 1 | 7.28 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 6.03 |
| CHEMBL129396 | — | — | 1 | 5.96 |
| CHEMBL4573345 | — | — | 1 | 4.64 |
| CHEMBL45408 | — | — | 1 | - |
| CHEMBL269881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579344 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL298445 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 925.0 | nM | 6.03 |
| CHEMBL129396 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4573345 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL45408 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL269881 | — | Ki | > | 100.0 | nM | - |