Assay Detail
Binding
CHEMBL4346832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PSB-603 from recombinant human A2B adenosine receptor expressed in CHO cell membranes measured after 75 mins in presence of adenosine deaminase by liquid scintillation counting method
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A<sub>2B</sub> Adenosine Receptor Antagonists with Picomolar Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 8.92 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4552275 | — | — | 1 | 10.08 |
| CHEMBL4450864 | — | — | 1 | 9.86 |
| CHEMBL4464522 | — | — | 1 | 9.83 |
| CHEMBL4540206 | — | — | 1 | 9.81 |
| CHEMBL4454481 | — | — | 1 | 9.80 |
| CHEMBL4463929 | — | — | 1 | 9.67 |
| CHEMBL4466625 | — | — | 1 | 9.63 |
| CHEMBL4567785 | — | — | 1 | 9.61 |
| CHEMBL4460114 | — | — | 1 | 9.47 |
| CHEMBL4530074 | — | — | 1 | 9.45 |
| CHEMBL4440526 | — | — | 1 | 9.40 |
| CHEMBL4441276 | — | — | 1 | 9.39 |
| CHEMBL4454417 | — | — | 1 | 9.38 |
| CHEMBL4443090 | — | — | 1 | 9.37 |
| CHEMBL4566170 | — | — | 1 | 9.32 |
| CHEMBL4456096 | — | — | 1 | 9.21 |
| CHEMBL4466765 | — | — | 1 | 9.20 |
| CHEMBL4464175 | — | — | 1 | 9.20 |
| CHEMBL4471205 | — | — | 1 | 9.19 |
| CHEMBL4572369 | — | — | 1 | 9.19 |
| CHEMBL4464738 | — | — | 1 | 9.15 |
| CHEMBL4453324 | — | — | 1 | 9.05 |
| CHEMBL4467573 | — | — | 1 | 8.99 |
| CHEMBL4556744 | — | — | 1 | 8.91 |
| CHEMBL4437222 | — | — | 1 | 8.89 |
| CHEMBL4473749 | — | — | 1 | 8.77 |
| CHEMBL4461478 | — | — | 1 | 8.72 |
| CHEMBL4537196 | — | — | 1 | 8.72 |
| CHEMBL4466211 | — | — | 1 | 8.49 |
| CHEMBL4538468 | — | — | 1 | 8.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552275 | — | Ki | = | 0.0835 | nM | 10.08 |
| CHEMBL4450864 | — | Ki | = | 0.137 | nM | 9.86 |
| CHEMBL4464522 | — | Ki | = | 0.148 | nM | 9.83 |
| CHEMBL4540206 | — | Ki | = | 0.153 | nM | 9.81 |
| CHEMBL4454481 | — | Ki | = | 0.159 | nM | 9.80 |
| CHEMBL4463929 | — | Ki | = | 0.215 | nM | 9.67 |
| CHEMBL4466625 | — | Ki | = | 0.234 | nM | 9.63 |
| CHEMBL4567785 | — | Ki | = | 0.244 | nM | 9.61 |
| CHEMBL4460114 | — | Ki | = | 0.342 | nM | 9.47 |
| CHEMBL4530074 | — | Ki | = | 0.352 | nM | 9.45 |
| CHEMBL4440526 | — | Ki | = | 0.397 | nM | 9.40 |
| CHEMBL4441276 | — | Ki | = | 0.403 | nM | 9.39 |
| CHEMBL4454417 | — | Ki | = | 0.421 | nM | 9.38 |
| CHEMBL4443090 | — | Ki | = | 0.432 | nM | 9.37 |
| CHEMBL4566170 | — | Ki | = | 0.473 | nM | 9.32 |
| CHEMBL4456096 | — | Ki | = | 0.616 | nM | 9.21 |
| CHEMBL4466765 | — | Ki | = | 0.632 | nM | 9.20 |
| CHEMBL4464175 | — | Ki | = | 0.629 | nM | 9.20 |
| CHEMBL4471205 | — | Ki | = | 0.644 | nM | 9.19 |
| CHEMBL4572369 | — | Ki | = | 0.643 | nM | 9.19 |
| CHEMBL4464738 | — | Ki | = | 0.706 | nM | 9.15 |
| CHEMBL4453324 | — | Ki | = | 0.894 | nM | 9.05 |
| CHEMBL4467573 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL4556744 | — | Ki | = | 1.24 | nM | 8.91 |
| CHEMBL4437222 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL4473749 | — | Ki | = | 1.69 | nM | 8.77 |
| CHEMBL4461478 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL4537196 | — | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL4466211 | — | Ki | = | 3.22 | nM | 8.49 |
| CHEMBL4538468 | — | Ki | = | 3.55 | nM | 8.45 |
| CHEMBL4547661 | — | Ki | = | 4.31 | nM | 8.37 |
| CHEMBL4582353 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4543948 | — | Ki | = | 5.69 | nM | 8.24 |
| CHEMBL4445941 | — | Ki | = | 6.08 | nM | 8.22 |
| CHEMBL4575279 | — | Ki | = | 7.02 | nM | 8.15 |
| CHEMBL4586090 | — | Ki | = | 7.15 | nM | 8.15 |
| CHEMBL4583860 | — | Ki | = | 8.34 | nM | 8.08 |
| CHEMBL4529435 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL4581448 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL4455937 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL4521715 | — | Ki | = | 96.7 | nM | 7.01 |