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Assay Detail

CHEMBL4346910

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SMMC7721 cells incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SMMC-7721
Confidence 1 — Organism
Curated By Autocuration

Target

SMMC-7721 (CHEMBL613831)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives.
Yu JY, Li XQ, Wei MX.
Eur J Med Chem (2019) 169 : 21 -28
PubMed 30852384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.79 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4581557 1 8.60
CHEMBL4446747 1 8.15
CHEMBL4436781 1 7.99
CHEMBL90555 VINCRISTINE 4.0 1 7.99
CHEMBL4556604 1 7.94
CHEMBL4581720 1 7.80
CHEMBL4452000 1 7.78
CHEMBL4460328 1 7.62
CHEMBL4437325 1 7.61
CHEMBL4435480 1 7.58
CHEMBL803 CYTARABINE 4.0 1 7.57
CHEMBL4550883 1 7.55
CHEMBL4452684 1 7.48
CHEMBL4464010 1 7.43
CHEMBL307261 ARTENIMOL 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4581557 IC50 = 2.5 nM 8.60
CHEMBL4446747 IC50 = 7.0 nM 8.15
CHEMBL4436781 IC50 = 10.2 nM 7.99
CHEMBL90555 VINCRISTINE IC50 = 10.3 nM 7.99
CHEMBL4556604 IC50 = 11.4 nM 7.94
CHEMBL4581720 IC50 = 16.0 nM 7.80
CHEMBL4452000 IC50 = 16.7 nM 7.78
CHEMBL4460328 IC50 = 23.7 nM 7.62
CHEMBL4437325 IC50 = 24.3 nM 7.61
CHEMBL4435480 IC50 = 26.0 nM 7.58
CHEMBL803 CYTARABINE IC50 = 27.1 nM 7.57
CHEMBL4550883 IC50 = 28.4 nM 7.55
CHEMBL4452684 IC50 = 33.2 nM 7.48
CHEMBL4464010 IC50 = 37.1 nM 7.43
CHEMBL307261 ARTENIMOL IC50 > 100.0 nM -