Assay Detail
Binding
CHEMBL4347286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL1075310) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.44 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | 1.0 | 1 | 4.66 |
| CHEMBL293492 | CINNAMALDEHYDE | -1.0 | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL293492 | CINNAMALDEHYDE | EC50 | = | 61000.0 | nM | 4.21 |