Assay Detail
Functional
CHEMBL4347331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human PANC1 cells in nutrient-deprived medium incubated for 24 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of tetrahydroquinolin-2(1H)-one derivatives as novel anti-pancreatic cancer agents via targeting autophagy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.22 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435734 | ARCTIGENIN | — | 1 | 5.66 |
| CHEMBL4554560 | — | — | 1 | 5.31 |
| CHEMBL4543336 | — | — | 1 | 5.28 |
| CHEMBL4444719 | — | — | 1 | 5.24 |
| CHEMBL4560814 | — | — | 1 | 5.20 |
| CHEMBL4558537 | — | — | 1 | 5.17 |
| CHEMBL4452688 | — | — | 1 | 5.15 |
| CHEMBL4556016 | — | — | 1 | 5.14 |
| CHEMBL4583485 | — | — | 1 | 5.14 |
| CHEMBL4435756 | — | — | 1 | 5.13 |
| CHEMBL4436936 | — | — | 1 | 5.11 |
| CHEMBL4456740 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435734 | ARCTIGENIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4554560 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4543336 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4444719 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4560814 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4558537 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4452688 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4556016 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4583485 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4435756 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4436936 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4456740 | — | IC50 | = | 7700.0 | nM | 5.11 |