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Assay Detail

CHEMBL4347502

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HT-29 cells incubated for 2 days by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel multitarget inhibitors with antiangiogenic and immunomodulator properties.
Conesa-Milián L, Falomir E, Murga J, Carda M, Marco JA.
Eur J Med Chem (2019) 170 : 87 -98
PubMed 30878834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.04 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4535136 1 6.28
CHEMBL4586070 1 5.82
CHEMBL4439814 1 5.46
CHEMBL535 SUNITINIB 4.0 1 5.42
CHEMBL4452195 1 4.92
CHEMBL4445564 1 4.85
CHEMBL1336 SORAFENIB 4.0 1 4.77
CHEMBL4099869 1 4.72
CHEMBL4472839 1 4.70
CHEMBL4570579 1 4.70
CHEMBL4524155 1 4.48
CHEMBL4448636 1 4.33
CHEMBL4578275 1 -
CHEMBL4593366 1 -
CHEMBL4459023 1 -
CHEMBL4529831 1 -
CHEMBL4448455 1 -
CHEMBL4581003 1 -
CHEMBL4579588 1 -
CHEMBL4590349 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4535136 IC50 = 520.0 nM 6.28
CHEMBL4586070 IC50 = 1500.0 nM 5.82
CHEMBL4439814 IC50 = 3500.0 nM 5.46
CHEMBL535 SUNITINIB IC50 = 3800.0 nM 5.42
CHEMBL4452195 IC50 = 12000.0 nM 4.92
CHEMBL4445564 IC50 = 14000.0 nM 4.85
CHEMBL1336 SORAFENIB IC50 = 17000.0 nM 4.77
CHEMBL4099869 IC50 = 19000.0 nM 4.72
CHEMBL4472839 IC50 = 20000.0 nM 4.70
CHEMBL4570579 IC50 = 20000.0 nM 4.70
CHEMBL4524155 IC50 = 33000.0 nM 4.48
CHEMBL4448636 IC50 = 47000.0 nM 4.33
CHEMBL4578275 IC50 > 200000.0 nM -
CHEMBL4593366 IC50 > 200000.0 nM -
CHEMBL4459023 IC50 > 200000.0 nM -
CHEMBL4529831 IC50 > 200000.0 nM -
CHEMBL4448455 IC50 > 200000.0 nM -
CHEMBL4581003 IC50 > 200000.0 nM -
CHEMBL4579588 IC50 > 200000.0 nM -
CHEMBL4590349 IC50 > 200000.0 nM -