Assay Detail
Binding
CHEMBL4347601
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Inhibition of recombinant human JAK1 using Ulight-CAGAGAIETDKEYYTVKD as substrate measured after 60 mins by LANCE assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.00 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453646 | — | — | 1 | 8.47 |
| CHEMBL4526274 | — | — | 1 | 8.32 |
| CHEMBL4575813 | — | — | 1 | 8.00 |
| CHEMBL4466059 | — | — | 1 | 7.85 |
| CHEMBL4471710 | — | — | 1 | 7.82 |
| CHEMBL4562491 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453646 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4526274 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4575813 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4466059 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4471710 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4562491 | — | IC50 | = | 30.0 | nM | 7.52 |