Assay Detail
Functional
CHEMBL4348089
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Antiviral activity against HSV-1 infected in African green monkey Vero cells preincubated with virus for 5 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: High activity against tick-borne encephalitis virus and non-specific activity against enterovirus A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797928 | — | — | 1 | 8.70 |
| CHEMBL3798024 | — | — | 1 | 7.32 |
| CHEMBL4472240 | — | — | 1 | 7.06 |
| CHEMBL4473048 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797928 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3798024 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4472240 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4473048 | — | EC50 | = | 190.0 | nM | 6.72 |