Assay Detail
Functional
CHEMBL4348126
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Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.56 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.93 |
| CHEMBL4442478 | — | — | 1 | 5.86 |
| CHEMBL4469794 | — | — | 1 | 5.75 |
| CHEMBL4459091 | — | — | 1 | 5.70 |
| CHEMBL4555383 | — | — | 1 | 5.67 |
| CHEMBL4581642 | — | — | 1 | 5.07 |
| CHEMBL4534246 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4442478 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4469794 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4459091 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4555383 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4581642 | — | IC50 | = | 8610.0 | nM | 5.07 |
| CHEMBL4534246 | — | IC50 | = | 12310.0 | nM | 4.91 |