Assay Detail
ADMET
CHEMBL4348250
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Antiproliferative activity against human NHDF cells incubated for 72 hrs by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NHDF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.04 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435401 | — | — | 1 | 6.55 |
| CHEMBL4448539 | — | — | 1 | 5.49 |
| CHEMBL4455620 | — | — | 1 | 4.99 |
| CHEMBL4438261 | — | — | 1 | 4.92 |
| CHEMBL4539081 | — | — | 1 | 4.91 |
| CHEMBL4587686 | — | — | 1 | 4.89 |
| CHEMBL4547135 | — | — | 1 | 4.88 |
| CHEMBL4454477 | — | — | 1 | 4.88 |
| CHEMBL4450861 | — | — | 1 | 4.83 |
| CHEMBL4468050 | — | — | 1 | 4.78 |
| CHEMBL385064 | — | — | 1 | 4.72 |
| CHEMBL4440736 | — | — | 1 | 4.67 |
| CHEMBL4448387 | — | — | 1 | - |
| CHEMBL4521459 | — | — | 1 | - |
| CHEMBL4584891 | — | — | 1 | - |
| CHEMBL4552738 | — | — | 1 | - |
| CHEMBL4540209 | — | — | 1 | - |
| CHEMBL4474864 | — | — | 1 | - |
| CHEMBL4570024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435401 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4448539 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4455620 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4438261 | — | IC50 | = | 12090.0 | nM | 4.92 |
| CHEMBL4539081 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL4587686 | — | IC50 | = | 12870.0 | nM | 4.89 |
| CHEMBL4547135 | — | IC50 | = | 13280.0 | nM | 4.88 |
| CHEMBL4454477 | — | IC50 | = | 13060.0 | nM | 4.88 |
| CHEMBL4450861 | — | IC50 | = | 14740.0 | nM | 4.83 |
| CHEMBL4468050 | — | IC50 | = | 16660.0 | nM | 4.78 |
| CHEMBL385064 | — | IC50 | = | 18880.0 | nM | 4.72 |
| CHEMBL4440736 | — | IC50 | = | 21340.0 | nM | 4.67 |
| CHEMBL4448387 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4521459 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4584891 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4552738 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4540209 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4474864 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4570024 | — | IC50 | > | 25000.0 | nM | - |