Assay Detail
Functional
CHEMBL4348289
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Antiproliferative activity against human HeLa cells measured after 3 days by Coulter counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.10 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.06 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 7.89 |
| CHEMBL4451061 | — | — | 1 | 7.48 |
| CHEMBL4445402 | — | — | 1 | 7.41 |
| CHEMBL4572727 | — | — | 1 | 7.27 |
| CHEMBL4518432 | — | — | 1 | 7.12 |
| CHEMBL4463629 | — | — | 1 | 7.10 |
| CHEMBL4582489 | — | — | 1 | 7.09 |
| CHEMBL4443573 | — | — | 1 | 7.03 |
| CHEMBL4440418 | — | — | 1 | 6.89 |
| CHEMBL4471495 | — | — | 1 | 6.80 |
| CHEMBL4462222 | — | — | 1 | 6.75 |
| CHEMBL4444432 | — | — | 1 | 6.30 |
| CHEMBL4516438 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4451061 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4445402 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4572727 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4518432 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4463629 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4582489 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4443573 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4440418 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4471495 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4462222 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4444432 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4516438 | — | IC50 | = | 550.0 | nM | 6.26 |