Assay Detail
Functional
CHEMBL4348290
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Antiproliferative activity against mouse L1210 cells measured after 96 hrs by Coulter counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.16 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.00 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 7.89 |
| CHEMBL4451061 | — | — | 1 | 7.58 |
| CHEMBL4445402 | — | — | 1 | 7.40 |
| CHEMBL4582489 | — | — | 1 | 7.28 |
| CHEMBL4443573 | — | — | 1 | 7.24 |
| CHEMBL4518432 | — | — | 1 | 7.24 |
| CHEMBL4572727 | — | — | 1 | 7.19 |
| CHEMBL4463629 | — | — | 1 | 7.07 |
| CHEMBL4471495 | — | — | 1 | 6.85 |
| CHEMBL4462222 | — | — | 1 | 6.72 |
| CHEMBL4440418 | — | — | 1 | 6.72 |
| CHEMBL4444432 | — | — | 1 | 6.60 |
| CHEMBL4516438 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4451061 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4445402 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4582489 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4443573 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4518432 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4572727 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4463629 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4471495 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4462222 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4440418 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4444432 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4516438 | — | IC50 | = | 330.0 | nM | 6.48 |