Assay Detail
Functional
CHEMBL4348291
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Antiproliferative activity against human HMEC1 cells measured after 4 days by Coulter counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.20 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 8.54 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.42 |
| CHEMBL4451061 | — | — | 1 | 7.54 |
| CHEMBL4582489 | — | — | 1 | 7.39 |
| CHEMBL4445402 | — | — | 1 | 7.33 |
| CHEMBL4443573 | — | — | 1 | 7.23 |
| CHEMBL4471495 | — | — | 1 | 7.08 |
| CHEMBL4462222 | — | — | 1 | 7.00 |
| CHEMBL4572727 | — | — | 1 | 6.85 |
| CHEMBL4518432 | — | — | 1 | 6.85 |
| CHEMBL4463629 | — | — | 1 | 6.80 |
| CHEMBL4440418 | — | — | 1 | 6.75 |
| CHEMBL4444432 | — | — | 1 | 6.58 |
| CHEMBL4516438 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL107 | COLCHICINE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4451061 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4582489 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4445402 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4443573 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4471495 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4462222 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4572727 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4518432 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4463629 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4440418 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4444432 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4516438 | — | IC50 | = | 360.0 | nM | 6.44 |