Assay Detail
Functional
CHEMBL4348376
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability preincubated for 5 hrs followed by compound washout and subsequent 3 mW/cm2 UVA irradiation measured 48 hrs post irradiation by CCK8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthyl quinoxaline thymidine conjugate is a potent anticancer agent post UVA activation and elicits marked inhibition of tumor growth through vaccination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.47 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470956 | — | — | 1 | 7.63 |
| CHEMBL4445734 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470956 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4445734 | — | IC50 | = | 49.6 | nM | 7.30 |