Assay Detail
Functional
CHEMBL4348489
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Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.57 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.79 |
| CHEMBL4447747 | — | — | 1 | 5.76 |
| CHEMBL4519408 | — | — | 1 | 5.64 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.64 |
| CHEMBL4450345 | — | — | 1 | 5.61 |
| CHEMBL4461727 | — | — | 1 | 5.59 |
| CHEMBL4452463 | — | — | 1 | 5.53 |
| CHEMBL4558432 | — | — | 1 | 5.51 |
| CHEMBL4554640 | — | — | 1 | 5.51 |
| CHEMBL4519546 | — | — | 1 | 5.38 |
| CHEMBL4586917 | — | — | 1 | 5.34 |
| CHEMBL4575542 | — | — | 1 | - |
| CHEMBL4445053 | — | — | 1 | - |
| CHEMBL4523049 | — | — | 1 | - |
| CHEMBL4473467 | — | — | 1 | - |
| CHEMBL4472611 | — | — | 1 | - |
| CHEMBL4437262 | — | — | 1 | - |
| CHEMBL4470529 | — | — | 1 | - |
| CHEMBL4466920 | — | — | 1 | - |
| CHEMBL4573193 | — | — | 1 | - |
| CHEMBL4590579 | — | — | 1 | - |
| CHEMBL4465558 | — | — | 1 | - |
| CHEMBL4456460 | — | — | 1 | - |
| CHEMBL4437160 | — | — | 1 | - |
| CHEMBL4464571 | — | — | 1 | - |
| CHEMBL4463949 | — | — | 1 | - |
| CHEMBL4554368 | — | — | 1 | - |
| CHEMBL4456914 | — | — | 1 | - |
| CHEMBL4557617 | — | — | 1 | - |
| CHEMBL4518307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4447747 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4519408 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4450345 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4461727 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4452463 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4558432 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL4554640 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4519546 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL4586917 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL4575542 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4445053 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4523049 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4473467 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4472611 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4437262 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4470529 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4466920 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4573193 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4590579 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4465558 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4456460 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4437160 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4464571 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4463949 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4554368 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4456914 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4557617 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4518307 | — | IC50 | > | 5000.0 | nM | - |