Assay Detail
Binding
CHEMBL4348552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-3/gamma-2 (CHEMBL2094121) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.42 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299611 | — | — | 1 | 8.57 |
| CHEMBL178942 | — | — | 1 | 7.15 |
| CHEMBL50581 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299611 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL178942 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL50581 | — | Ki | = | 280.0 | nM | 6.55 |