Assay Detail
Binding
CHEMBL4348555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-5/beta-3/gamma-2 (CHEMBL2094122) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.61 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299611 | — | — | 1 | 9.48 |
| CHEMBL178942 | — | — | 1 | 8.92 |
| CHEMBL50581 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299611 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL178942 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL50581 | — | Ki | = | 38.0 | nM | 7.42 |